报 告题目： QTY Code: a simple tool for protein engineering

报   告   人： Dr. Shuguang Zhang, Laboratory of Molecular Architecture Center for Bits & Atoms, Massachusetts Institute of Technology

时        间：2016年8月16日（星期二），上午10:00

地        点：南楼2层会议室

邀 请 人：杨延莲 研究员（Tel：82545559）

摘要：

Shuguang Zhang made a serendipitous discovery of a repetitious and ionic selfcomplementary peptide segment in yeast protein Zuotin in 1990. This is discovery of the first self-assembling peptides that eventually led to the development of a new field of peptide nanobiotecnology. Furthermore, his discovery inspired numerous people around the world to design a variety of self-assembling peptides for wide spread uses including peptide hydrogels in materials science, 3D tissue cell culture and tissue engineering, nanomedicine, sustained molecular releases, clinical and surgical applications. He co-founded a startup company that has made significant contribution to bring the self-assembling peptide materials to human clinical and surgical uses.

Shuguang Zhang in 2011 invented a simple molecular QTY code to engineer proteins particularly membrane proteins and perhaps other aggregated proteins. Not only these engineered membrane receptor proteins become water-soluble with little changing molecular weight and pI, but also these detergent-free (water-soluble) membrane proteins retain their biological function, namely bind their natural ligands. This simple QTY code will likely have a big impact in engineering a variety of membrane proteins and perhaps some water-insoluble and aggregated proteins.

报告人简介：

Dr. Shuguang Zhang （张曙光）is at Center for Bits & Atoms, Massachusetts Institute of Technology. He received his B.S from Sichuan University, China and Ph.D. in Biochemistry & Molecular Biology from University of California at Santa Barbara, USA. He was an American Cancer Society Postdoctoral Fellow and a Whitaker Foundation Investigator at MIT. He was a 2003 Fellow of Japan Society for Promotion of Science (JSPS fellow). His work of designer self-assembling peptide scaffold won 2004 R&D100 award. His and his colleagues’ work for direct harvesting biosola energy was selected one of the 10 finalists of the 2005 Saatchi & Saatchi Award for World Changing Ideas. He won 2006 Wilhelm Exner Medal of Austria. He is a Fellow of American Institute of Medical and Biological Engineering and Fellow of US National Academy of Inventors. He is a Foreign Corresponding Member of Austrian Academy of Sciences. He published> 160 scientific papers that have so far been cited ~22,000 times, with h-index 71. He is also a co-founder and board member of Molecular Frontiers Foundation that encourages young people to ask big and good questions in order to win Molecular Frontiers Inquiry Prize.